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Literature summary for 2.7.11.11 extracted from

  • Walker-Gray, R.; Stengel, F.; Gold, M.G.
    Mechanisms for restraining cAMP-dependent protein kinase revealed by subunit quantitation and cross-linking approaches (2017), Proc. Natl. Acad. Sci. USA, 114, 10414-10419 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.11

Organism

Organism UniProt Comment Textmining
Homo sapiens P22694
-
-
Rattus norvegicus P27791
-
-
Rattus norvegicus Sprague-Dawley P27791
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-

Source Tissue

Source Tissue Comment Organism Textmining
cerebellum
-
 Rattus norvegicus
-
forebrain
-
 Rattus norvegicus
-
heart
-
 Rattus norvegicus
-
HEK-293 cell
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
lung
-
 Rattus norvegicus
-
skeletal muscle
-
 Rattus norvegicus
-

Subunits

Subunits Comment Organism
More catalytic subunits are released from regulatory subunits by cAMP. Regulatory subunits are expressed much more highly than catalytic subunits to support rapid catalytic subunit reassociation Homo sapiens
More catalytic subunits are released from regulatory subunits by cAMP. Regulatory subunits are expressed much more highly than catalytic subunits to support rapid catalytic subunit reassociation Rattus norvegicus

Synonyms

Synonyms Comment Organism
PKACbeta
-
 Homo sapiens
PKACbeta
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function protein phosphorylation by cAMP-dependent protein kinase (PKA) triggers cellular changes, including fight-or-flight responses in heart cells, and synaptic potentiation in neurons Homo sapiens
physiological function protein phosphorylation by cAMP-dependent protein kinase (PKA) triggers cellular changes, including fight-or-flight responses in heart cells, and synaptic potentiation in neurons Rattus norvegicus
physiological function uncontrolled activity of PKA catalytic subunits is pathological Homo sapiens
physiological function uncontrolled activity of PKA catalytic subunits is pathological Rattus norvegicus